Imaging Predicts Long-Term Effects in Veterans With Brain Injury
Diffusion tensor imaging (DTI), a type of MRI, may be able to predict functional postdeployment outcomes for veterans who sustained mild traumatic brain injury (MTBI), or concussion, during combat, according to a study published in the journal Radiology.

Current assessment of MTBI remains challenging due to the difficulties in establishing the diagnosis, predicting outcomes, and separating the effects of MTBI from other conditions like posttraumatic stress disorder.

DTI uses measurements of water movement in the brain to detect abnormalities, particularly in white matter. Previous studies have linked DTI metrics to neurocognitive function and short-term functional outcomes in groups of patients. The desire to uncover possible long-term effects spurred Jeffrey B. Ware, MD, from the Philadelphia VA Medical Center, to evaluate combat veterans using this technique.

Ware and colleagues used brain MRI and DTI to study 57 military veterans who had a clinical diagnosis of MTBI upon return from deployment. The average length of time between injury and postdeployment evaluation was 3.8 years with an average follow-up duration of 1.4 years.

"All conventional MR images were interpreted as normal," Ware says. "We retrospectively analyzed the data from the DTI sequence to derive measures of white matter integrity, which we compared to clinical measures and subsequent outcome measures six months to 2.5 years after the initial evaluation."

The results showed significant associations between initial postdeployment DTI measurements and neurobehavioral symptoms, timing of injury, and subsequent functional outcomes. The measurements also correlated with greater health care utilization among veterans with MTBI.

Following initial postdeployment evaluation, 34 of the study participants returned to work. Veterans who did not return to work displayed significantly lower fractional anisotropy and higher diffusivity in a specific brain region, the left internal capsule. These measures imply less structural integrity in that area of the brain. As this region is known to contain important fibers providing motor stimulation to the typically dominant right side of the body, the results may provide a correlation between impairments in fine motor functioning and inability to return to work.

"Our findings suggest that differences in white matter microstructure may partially account for the variance in functional outcomes among this population. In particular, loss of white matter integrity has a direct, measurable effect," Ware says. "It was illuminating to see the association between measures of white matter integrity and important outcomes occurring months to years down the road in our study population."